Question: Does high cholesterol affect the clotting cascade?
There is not much I could find on a brief search. The papers I found seem to support the established teaching that elevated triglycerides or cholesterol seem to promote inappropriate clotting increasing the risk of cardiovascular disease. The effect this has in trauma does not seem to be as well defined. Though there may be some effect on long term healing (not well studied) - the immediate problem and treatment of injury appears to be unchanged.
Papers included as matter of interest only- not great data....
R Krysiak, B Okopein, "Effect of simvastatin on hemostasis in patients with isolated hypertriglyceridemia". Pharmacology 92|(3-4):187-90. 2013.
- statin prolonged PT/PTT
W Chung, et. al. "Hyperlipidemia and statins affect neurological outcome in lumbar spine surgery." Int Journal of Environmental Research and Public Health". 12(1):402-13. 05 Jan 15.
Evidence Based Medicine
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